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Nadja Paeslack Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, Germany

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Christoph Reinhardt Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, Germany
German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany

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extrinsic nutritional factor that was demonstrated to increase mucosal thickness and villus length in the small intestine ( Todorov et al. 2020 ). In contrast, epithelial-to-mesenchymal signaling by endogenous intrinsically synthetized morphogens, such as

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Victoria Poplaski Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

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Faith Sawyer Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

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Sarah E Blutt Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

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composition in the small intestine ( Human Microbiome Project 2012 ), and a recent focus on the functionality of these organisms has resulted in the discovery that the microbiome and ISCs have an intimate relationship ( Peck et al. 2017 ). This review will

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Josey Muske Mayo Graduate School of Biomedical Sciences, Mayo Clinic Rochester, Minnesota, USA
Department of Immunology, Mayo Clinic Rochester, Minnesota, USA

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Kathryn Knoop Department of Immunology, Mayo Clinic Rochester, Minnesota, USA
Department of Pediatrics, Mayo Clinic Rochester, Minnesota, USA

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blood, serves as a primary site of pathogen clearance from the blood. d -lactate, a metabolite produced by commensal bacteria within the intestines able to be used systemically, promotes Kupffer cells – a subset of macrophages located in the vascular

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Sweta Ghosh Department of Microbiology and Immunology, Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, Kentucky, United States of America

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Syam P Nukavarapu Department of Biomedical Engineering and Department of Materials Science & Engineering, University of Connecticut, Storrs, Connecticut, United States of America

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Venkatakrishna Rao Jala Department of Microbiology and Immunology, Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, Kentucky, United States of America

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risk of diseases such as Crohn's disease in humans ( Cray et al. 2021 ). M cells are specialized epithelial cells found in the gut-associated lymphoid tissue (GALT) of Peyer’s patches of the small intestine, isolated lymphoid follicles, colonic

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Andrija Karačić Department of General Surgery, University Hospital Sveti Duh, Zagreb, Croatia
The Gut Microbiome Center (CCM), Zagreb, Croatia

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Jasna Novak Department of Biochemical Engineering, University of Zagreb Faculty of Food Technology and Biotechnology Faculty, Zagreb, Croatia

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Alan Ivković Department of Orthopaedics and Traumatology, University Hospital Sveti Duh, Zagreb, Croatia
School of Medicine, University of Zagreb, Zagreb, Croatia
Department of Clinical Medicine, University of Applied Health Sciences, Zagreb, Croatia

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probiotic administration in bone fracture treatment. Given that research in this area is in its infancy, only a small number of scientific articles are available, and in addition, because these are rather heterogeneous studies with specificities in

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John Henry Dasinger Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Bina Joe Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

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Justine M Abais-Battad Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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fatty acids directly impact central nervous system autoimmunity via the small intestine . Immunity 43 817 – 829 . ( https://doi.org/10.1016/j.immuni.2015.09.007 ) Haro C Rangel-Zuniga OA Alcala-Diaz JF , 2016 Intestinal microbiota is influenced

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Morgan A Maly Center for Conservation Genomics, Smithsonian National Zoo and Conservation Biology Institute, Washington, DC, USA
Department of Animal Care Science, Smithsonian National Zoo and Conservation Biology Institute, Front Royal, Virginia, USA
Department of Biological Sciences, College of Sciences, North Carolina State University, Raleigh, North Carolina, USA
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

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Adrienne E Crosier Department of Animal Care Science, Smithsonian National Zoo and Conservation Biology Institute, Front Royal, Virginia, USA

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Mia M Keady Center for Conservation Genomics, Smithsonian National Zoo and Conservation Biology Institute, Washington, DC, USA
Nelson Institute for Environmental Studies, University of Wisconsin-Madison, Madison, Wisconsin, USA

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Reade B Roberts Department of Biological Sciences, College of Sciences, North Carolina State University, Raleigh, North Carolina, USA

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Matthew Breen Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

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Carly R Muletz-Wolz Center for Conservation Genomics, Smithsonian National Zoo and Conservation Biology Institute, Washington, DC, USA

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observed small shifts in Firmicutes and increased dispersion in the community suggesting the beginning of changes to the community, the communities overall did not significantly change until 48 h post defecation. Our findings indicate microbial community

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