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Simran Kaur Cheema School of Biological Sciences, Institute for Global Food Security, Queen’s University Belfast, UK

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Ranran Li School of Biological Sciences, Institute for Global Food Security, Queen’s University Belfast, UK

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Simon J S Cameron School of Biological Sciences, Institute for Global Food Security, Queen’s University Belfast, UK

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ecosystem, compared to metagenomics, as these isolated microorganisms can be utilised in in vitro work to establish mechanisms of host–microbiota interactions. In 2012, the Lagier research group applied the first culturomics research workflow in the human

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Nadja Paeslack Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, Germany

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Christoph Reinhardt Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Johannes Gutenberg-University Mainz, Germany
German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany

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. ( https://doi.org/10.1016/j.molcel.2020.03.005 ) Kostic AD Howitt MR & Garrett WS 2013 Exploring host-microbiota interactions in animal models and humans . Genes and Development 27 701 – 718 . ( https://doi.org/10.1101/gad.212522.112 ) Kubis

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Bina Joe Center for Hypertension and Precision Medicine and Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, Ohio, USA

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microbiota residing with the host as a previously ignored feature contributing to a variety of pathologies. The vast scope of such host-microbiota interactions, which is now known to affect most, if not all host organs and their physiology, begs the question

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Victoria Poplaski Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

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Faith Sawyer Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

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Sarah E Blutt Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

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. Genes and Development 17 1709 – 1713 . ( https://doi.org/10.1101/gad.267103 ) Poletti M Arnauts K Ferrante M , 2021 Organoid-based models to study the role of host-microbiota interactions in IBD . Journal of Crohn’s and Colitis 15 1222 – 1235

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Sweta Ghosh Department of Microbiology and Immunology, Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, Kentucky, United States of America

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Syam P Nukavarapu Department of Biomedical Engineering and Department of Materials Science & Engineering, University of Connecticut, Storrs, Connecticut, United States of America

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Venkatakrishna Rao Jala Department of Microbiology and Immunology, Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, Kentucky, United States of America

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), purinergic receptor, and G-protein coupled receptors (GPR 41, GPR43, GPR109A) ( Liu et al. 2022 a , c ). These receptors play crucial roles in host–microbiota interactions and are expressed at various levels in different cell types such as IECs

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